South-Eastern European space (SEES) is the poorest area on the continent. The last years of European development show an increasing gap between the periphery and European core. This decay could be diminished by increasing the competitiveness of SEES? Searching an appropriate answer the presentation defines the study area, makes a synthesis on the main features of the space, and tries to design the general framework for increasing of the competitiveness. To mitigate the European discrepancies and to alleviate some dangerous trends for the future should have an appropriate framework for the next steps. The first step is to make an ojective analysis on the obstacles and strengths of this area. In this context, the presentation defines the weaknesses of this area, starting from the history until present-day geopolitical situation. How the people could realize that only together it’s possible to touch the performance in the territorial development? Historical tolerance, proximities, complementary resources, dispersion of good experiences a.s.o. could represent some solutions for diminishing the role of obstacles. This area has many strong points, and the capacity of decision makers at all levels is essential to valorize them. Taking into account the human potential with its stock of intelligence, natural resources, the importance of the metropolis in the development of SEES, this space has the chance to become more competitive. At the same time, the opportunities created by the Danube Valley, the Mediteranean Sea and Black Sea constitute real premises to accelerate the development. Obviously, another huge opportunity is represented by the European Union countries, which serve as an axis for this space. From strategic point of view it is very important to define and implement a sustainable and fruitful cooperation policy using the regional resources and their diversity.